Synapse- and Cell-Type-Specific Dysfunction in a Dravet Syndrome Mouse Model
Sharon Swanger, Ph.D., Assistant Professor, Fralin Biomedical Research Institute at VTC – Virginia Tech
Wed. May 25, 2022
10:55 – 11:20 a.m.
Washington Room, Hotel Roanoke
Abstract: Synapse diversity contributes to functional heterogeneity among brain circuits as well as circuit-specific disease susceptibility. Elucidating the molecular underpinnings of synapse diversity defines what governs information transfer within distinct brain circuits and identifies why specific synapses or cell-types are vulnerable to dysregulation. This presentation will address the synaptic and cellular mechanisms underlying thalamic circuit dysfunction in a mouse model of epileptic encephalopathy and introduce pharmacological strategies for modulating the dysregulated circuit components.