Synapse- and Cell-Type-Specific Dysfunction in a Dravet Syndrome Mouse Model

Sharon Swanger to present at Precision Neuroscience Conference
  • Sharon Swanger, Ph.D., Assistant Professor, Fralin Biomedical Research Institute at VTC – Virginia Tech

  • Wed. May 25, 2022

  • 10:55 – 11:20 a.m.

  • Washington Room, Hotel Roanoke

Abstract: Synapse diversity contributes to functional heterogeneity among brain circuits as well as circuit-specific disease susceptibility. Elucidating the molecular underpinnings of synapse diversity defines what governs information transfer within distinct brain circuits and identifies why specific synapses or cell-types are vulnerable to dysregulation. This presentation will address the synaptic and cellular mechanisms underlying thalamic circuit dysfunction in a mouse model of epileptic encephalopathy and introduce pharmacological strategies for modulating the dysregulated circuit components.

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